Beilstein J. Org. Chem.2022,18, 1763–1771, doi:10.3762/bjoc.18.185
data, mass spectrometry sequence tagging, advanced Marfey’s analysis, and the GNPS molecularnetworking we solved the full structure of digyalipopeptide A (1). We found that compound 1 is a member of a somewhat homologous series of peptides produced as a mixture by the strain containing the same amino
environment and their ability to be biologically active across different species.
Keywords: Leishmania; lipopeptides; molecularnetworking; sequence tagging; trypanosomes; Introduction
Microbes belonging to the genus Bacillus are mainly Gram-positive with only a few examples characterized as Gram-negative
to confirm the presence of the cyclic ester and the possible absolute stereochemistry around C-39 (δC 71.6) of the fatty acid chain we first of all consulted the global natural products social molecularnetworking (GNPS) [19][20][21]. The GNPS network data (Figure 6) provided the opportunity to
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Graphical Abstract
Figure 1:
Primary structure of digyalipopeptide A (1).
Beilstein J. Org. Chem.2020,16, 2831–2853, doi:10.3762/bjoc.16.233
. Two consecutive catalytic cycles were run which displayed a remarkable reproducibility of the yields.
Up to now, handling the time domain of ion translocation did not play a role in artificial molecularnetworking. The next example demonstrates a fully reversible and cascaded signaling system allowing
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Graphical Abstract
Figure 1:
Some selected self-sorting outcomes and their qualitative and quantitative assessment.